Anti-Human CD8a (OKT8) Mouse IgG2a Recombinant Antibody proteintech 65604-1-MR
$59.00
In stock
SKU
65604-1-MR
CD8, CD8a molecule, Leu2, MAL, OKT8
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human | Immunogen: CD8a molecule |
| Applications: FC | Observed Molecular Weight: BC025715 |
| Formulation: PBS, Azide | GenBank Accession Number: 925 |
| Conjugate: Unconjugated | Gene Symbol: ENSG00000153563 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): AB_3670351 |
| Application: Flow Cytometry (FC) | RRID: Unconjugated |
| Dilution: FC : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells, on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T-cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). |
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