Anti-Human CD70 Rabbit Recombinant Antibody proteintech 98098-1-RR
$82.00
In stock
SKU
98098-1-RR
241325D8, CD27 L, CD27 ligand, CD27L, CD27-L
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: CD70 molecule |
| Applications: FC | Observed Molecular Weight: BC000725 |
| Formulation: PBS, Azide | GenBank Accession Number: 970 |
| Conjugate: Unconjugated | Gene Symbol: AB_3672245 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) | RRID: Liquid |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: P32970 |
| Host / Isotype: Recombinant | Background Information: CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis. |
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