IRS1 Polyclonal antibody proteintech 17509-1-AP
$449.00
In stock
SKU
17509-1-AP
HIRS 1, insulin receptor substrate 1, IRS 1, IRS-1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: CatNo: Ag11714 Product name: Recombinant human IRS1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 895-1243 aa of BC053895 Sequence: EYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), IP, Dot blot, ELISA | Observed Molecular Weight: 1242 aa, 132 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC053895 |
| Conjugate: Unconjugated | Gene Symbol: IRS1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3667 |
| Application: Western Blot (WB) | RRID: AB_10596914 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Ins receptor substrate 1 (IRS1) was the first cloned and characterized member of the IRS family which are involved in ins receptor (IR) and ins-like growth factor I receptor (IGF-IR) signaling (PMID: 10669726). IRS1 is phosphorylated by ins receptor tyrosine kinase and is involved in various cellular processes including DNA repair fidelity, transcriptional activity, and cell growth can support tumor development and progression (PMID: 11259577). Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance (). IRS1 has a predicted molecular weight of 132 kDa, however, as a result of its extensive serine phosphorylation it separates on a SDS gel as a band of approximately 160-185 kDa. |
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