Anti-Human CD42b (AK2) Mouse IgG2a Recombinant Antibody proteintech 65588-1-MR
$61.00
In stock
SKU
65588-1-MR
BSS, CD42B, CD42b alpha, GP1B, GP1BA
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: Human | Immunogen: glycoprotein Ib (platelet), alpha polypeptide |
| Applications: FC | Observed Molecular Weight: BC027955 |
| Formulation: PBS, Azide | GenBank Accession Number: 2811 |
| Conjugate: Unconjugated | Gene Symbol: ENSG00000185245 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): AB_3670338 |
| Application: Flow Cytometry (FC) | RRID: Unconjugated |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: CD42b, also known as platelet glycoprotein Ib alpha chain (GPIb alpha), is a type I transmembrane glycoprotein of 135-145 kDa (PMID: 2656709). It is expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are linked by a disulphide bond to form GPIb (PMID: 7660135). GPIb forms a noncovalent complex with CD42a (GPIX) and CD42d (GPV) and acts as a receptor for von Willebrand factor (vWF) and thrombin (PMID: 7660135; 3759960). The GPIb-V-IX complex mediates vWF-dependent platelet adhesion to blood vessels. Defects in the expression of CD42b result in Bernard-Soulier syndromes and platelet-type von Willebrand disease (PMID: 9371310). |
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