Anti-Human CD41/CD61 Rabbit Recombinant Antibody proteintech 98765-1-RR
$67.00
In stock
SKU
98765-1-RR
CD41, CD61, GPIIb/IIIa, GPIIb/IIIa receptor, αIIbβ3
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: CD41/CD61 |
| Applications: FC | |
| Formulation: PBS, Azide | GenBank Accession Number: Liquid |
| Conjugate: Unconjugated | Gene Symbol: Protein A purification |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): PBS with 0.09% sodium azide, pH 7.3. |
| Application: Flow Cytometry (FC) | RRID: Store at 2 - 8°C. Stable for one year after shipment. |
| Dilution: FC : 0.25 ug per 10^6 cells in a 100 ?l suspension | |
| Tested Reactivity: Human | |
| Host / Isotype: Recombinant | Background Information: The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen. |
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