Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody proteintech 98215-1-RR
$159.00
In stock
SKU
98215-1-RR
TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: tumor necrosis factor receptor superfamily, member 17 |
| Applications: FC | Observed Molecular Weight: BC058291 |
| Formulation: PBS, Azide | GenBank Accession Number: 608 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purfication |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Q02223 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087). |
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