ADAM17 Recombinant monoclonal antibody proteintech 84292-4-RR
$449.00
In stock
SKU
84292-4-RR
241305A2, ADAM 17, cSVP, Disintegrin and metalloproteinase domain-containing protein 17, EC:3.4.24.86
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: ADAM metallopeptidase domain 17 |
| Applications: WB, IHC, FC (Intra), ELISA | Observed Molecular Weight: 100-130 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ADAM17 |
| Conjugate: Unconjugated | Gene Symbol: 6868 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671836 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor (PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). |
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