Phospho-PDH E1 Alpha (Ser232) Recombinant monoclonal antibody proteintech 81491-1-RR
$449.00
In stock
SKU
81491-1-RR
p PDH E1 Alpha Ser232, p PDH E1 Alpha (Ser232), p PDH E1 Alpha, PDH E1 Alpha (Ser232), Phospho PDH E1 Alpha
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human | Immunogen: Peptide Predict reactive species |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 43 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC002406 |
| Conjugate: Unconjugated | Gene Symbol: PDHA1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5160 |
| Application: Western Blot (WB) | RRID: AB_2935428 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PDH E1 Alpha (PDHA1), as the major component of PDH, can be phosphorylated and inactivated by PDHK1. PDHA1 contains three serine residues (Ser232, Ser293, or Ser300) that can be reversibly phosphorylated by a dedicated family of four inhibitory pyruvate dehydrogenase kinases (PDHK1-4) and two reactivating phosphatases (PDP1, 2). Hypoxia induces the expression of PDHK1 and PDHK3 and hyperphosphorylates PDHA1. Phosphorylated PDHA1 inactivates the whole pyruvate dehydrogenase complex (PDC), reduces pyruvate entering into the tricarboxylic acid (TCA) cycle for oxidative phosphorylation, enhances the Warburg effect and promotes tumorigenesis. (PMID:?30993888, PMID:?34749809) |
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