Phospho-CHEK2 (Thr68) Recombinant monoclonal antibody proteintech 81740-1-RR
$449.00
In stock
SKU
81740-1-RR
CHK2, CHEK2, EC:2.7.11.1, Cds1 homolog, CDS1
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human | Immunogen: Peptide Predict reactive species |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 61 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC004207 |
| Conjugate: Unconjugated | Gene Symbol: CHEK2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 11200 |
| Application: Western Blot (WB) | RRID: AB_2935575 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Serine/threonine-protein kinase Chk2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in response to the initial damage. ATM phosphorylates CHEK2 on T68. Phosphorylation on T68 and subsequent full activation of CHEK2 was shown to require priming phosphorylation on adjacent residues by Polo-like kinase 3 (PLK3) and the dualspecificity tyrosine and serine/threoninekinase TTK/hMPS1. Additionally TTK appears to phosphorylate T68. Phosphorylation of T68 promotes the binding of the N-terminal SQ/TQ-rich cluster of one CHEK2 molecule with the FHA domain of another CHEK2 molecule. (PMID:?28553140, PMID:?18004398, PMID: 33322746) |
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