Anti-Human CD8 (UCHT4) Mouse IgG2a Recombinant Antibody proteintech 65559-1-MR
$88.00
In stock
SKU
65559-1-MR
CD8A, T-cell surface glycoprotein CD8 alpha chain, p32, MAL, Leu2
| Host / Isotype: Mouse / IgG2a | Class: Recombinant |
| Reactivity: human | Immunogen: Thymocytes and Sézary T cells Predict reactive species |
| Applications: FC | Observed Molecular Weight: 235 aa, 26 kDa |
| Formulation: PBS, Azide | GenBank Accession Number: CD8A |
| Conjugate: Unconjugated | Gene Symbol: 925 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): ENSG00000153563 |
| Application: Flow Cytometry (FC) | RRID: AB_3670313 |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG2a | Background Information: CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). |
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