WT1 Recombinant monoclonal antibody proteintech 82525-1-RR
$449.00
In stock
SKU
82525-1-RR
2J13, Wilms tumor 1, Wilms tumor protein
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: Wilms tumor 1 |
| Applications: WB, IP, ELISA | Observed Molecular Weight: 52-55 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: WT1 |
| Conjugate: Unconjugated | Gene Symbol: 7490 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3086487 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: The WT1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context, and it is required for the normal formation of the genitourinary system and mesothelial tissues. WT1 inhibits apoptosis through p53 and Bcl-2 and also inhibits the differentiation of leukemic cells. The function of WT1 may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has a lower affinity for DNA and can bind RNA. WT1 exists some isoforms with a range of molecular weight is 33-50 kDa. |
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