SREBF1 Recombinant monoclonal antibody proteintech 82684-3-RR
$449.00
In stock
SKU
82684-3-RR
1P4, bHLHd1, Class D basic helix-loop-helix protein 1, Processed sterol regulatory element-binding protein 1, SREBF 1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: sterol regulatory element binding transcription factor 1 |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 68 kDa, 125 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SREBF1 |
| Conjugate: Unconjugated | Gene Symbol: 6720 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670527 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor. These factors enter the nucleus where they bind to sterol regulatory elements (SRE) in the promoter regions of a number of genes whose products mediate the synthesis of cholesterol and fatty acids. [PMID: 21698267]. |
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