SLAMF7/CD319 Recombinant monoclonal antibody proteintech 84254-1-RR
$449.00
In stock
SKU
84254-1-RR
SLAMF7, 241320B6, CD2-like receptor-activating cytotoxic cells, CD319, CRACC
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: SLAM family member 7 |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 75 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SLAMF7 |
| Conjugate: Unconjugated | Gene Symbol: 57823 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671802 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: Signaling lymphocyte activation molecule (SLAM) family receptors is a group of type I transmembrane receptors belonging to the immunoglobulin superfamily (PMID: 37251372). The SLAM family contains nine members that contain an extracellular segment comprising two or four Ig-like domains (V-like variable and C2-like constant), a transmembrane region and a cytoplasmic tail (PMID: 29662641). They are involved in various physiological and pathological processes, including the regulation of immunological responses and the route of viral entry. SLAMF7, also known as CS1, CRACC or CD319, is expressed on NK cells, CD8+ T lymphocytes, B lymphocytes, and mature dendritic cells (PMID: 28861320). It exerts both activating and inhibitory effects depending on the expression status of SAP or EAT-2. SLAMF7 is overexpressed in multiple myeloma and makes it a target for immunotherapy (PMID: 28861320). The native molecular weight of SLAMF7 is 37 kDa and the apparent molecular mass shifts due to glycosylation (PMID: 11698418; 36381324). |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
