RNASEH2B Recombinant monoclonal antibody proteintech 84097-6-RR
$449.00
In stock
SKU
84097-6-RR
ribonuclease H2, subunit B, Ribonuclease H2 subunit B, DLEU8, Aicardi-Goutieres syndrome 2 protein, AGS2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: ribonuclease H2, subunit B |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 35 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: RNASEH2B |
| Conjugate: Unconjugated | Gene Symbol: 79621 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671663 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Ribonuclease H2 is the major nuclear enzyme degrading cellular RNA/DNA hybrids in eukaryotes and the sole nuclease known to be able to hydrolyze ribonucleotides misincorporated during genomic replication. RNASEH2B and RNASEH2C are the non-catalytic subunits of RNase H2 complex. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2), a genetically heterogeneous disease with clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. |
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