PMS1 Recombinant monoclonal antibody proteintech 83456-6-RR
$449.00
In stock
SKU
83456-6-RR
PMSL1, MLH2, hPMS1, HNPCC3, 240408D9
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: PMS1 postmeiotic segregation increased 1 (S. cerevisiae) |
| Applications: WB, IHC, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: BC096331 |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: 5378 |
| Conjugate: Unconjugated | Gene Symbol: AB_3671092 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:500-1:2000 | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: P54277 |
| Host / Isotype: Recombinant | Background Information: PMS1 Homolog 1 is a member of the DNA mismatch repair enzymes (MMREs) which is to eliminate the mismatch of insertions and deletions as a consequence of DNA polymerase errors at DNA synthesis in eukaryotes. PMS1 and MLH1 could form a heterodimer MutLβ that belongs to MMREs (PMID:25619773). In the MMR system, the MutS complex recognizes the DNA mispairs firstly, and then the Mlh1-Pms1 and other associated proteins such as PCNA, RFC, ExoI were recruited, inducing Exonuclease 1 (Exo1)-dependent and -independent MMR pathways (PMID:24981171). Mutations in this gene cause hereditary nonpolyposis colorectal cancer(HNPCC), which is also known as Lynch syndrome. It was reported that PMS1 is a widely expressed protein and located in the nucleus. Alternative splicing allows for 4 isoforms of PMS1 protein. |
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