Phospho-SYK (Tyr323) Recombinant monoclonal antibody proteintech 83331-1-RR
$449.00
In stock
SKU
83331-1-RR
DKFZp313N1010, FLJ25043, FLJ37489, Phospho-SYK (Tyr323), spleen tyrosine kinase, SYK, Tyrosine protein kinase SYK
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: Human | Immunogen: spleen tyrosine kinase |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 70 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SYK |
| Conjugate: Unconjugated | Gene Symbol: 6850 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): ENSG00000165025 |
| Application: Western Blot (WB) | RRID: AB_3670995 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Recombinant | Background Information: SYK(spleen tyrosine kinase) is a key regulator of signal transduction events,apoptosis and orderly cell cycle progression in B-lineage lymphoid cells. The study found that in human platelets, inhibition of PKC leads to Syk hyperphosphorylation on residues Tyr-525/526 whereas Tyr-323 and Tyr-352 phosphorylations are unaffected. PKC negatively regulates Syk activity, as evidenced by hyperphosphorylation of downstream targets, LAT and PLCγ2 upon PKC inhibition. (PMID: 23960082) |
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