NFKB2,p100 Recombinant monoclonal antibody proteintech 84022-5-RR
$449.00
In stock
SKU
84022-5-RR
NFKB2, 241126C9, DNA binding factor KBF2, DNA-binding factor KBF2, H2TF1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 100-110 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NFKB2 |
| Conjugate: Unconjugated | Gene Symbol: 4791 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): ENSG00000077150 |
| Application: Western Blot (WB) | RRID: AB_3671590 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Recombinant | Background Information: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. This antibody can bind p100 isoform of NFKB2 spefically, but not p52 isoform. |
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