MRC2 Recombinant monoclonal antibody proteintech 86028-1-RR
$449.00
In stock
SKU
86028-1-RR
C type mannose receptor 2, CD280, CLEC13E, C-type lectin domain family 13 member E, C-type mannose receptor 2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: mannose receptor, C type 2 |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 180 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: MRC2 |
| Conjugate: Unconjugated | Gene Symbol: 9902 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Mouse, Rat | Form: Q9UBG0 |
| Host / Isotype: Recombinant | Background Information: C-type mannose receptor 2 (MRC2), also known as CD280, CLEC13E, ENDO180, KIAA0709, or UPARAP, is a type I transmembrane glycoprotein that belongs to the macrophage mannose receptor protein family (PMID: 10683150; 10636902; 9734811). It contains an N-terminal cysteine-rich domain, a fibronectin type II domain (FNII), eight C-type-lectin-like domains, and a transmembrane region followed by a small cytoplasmic domain (PMID: 34012764). MRC2 is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation (PMID: 17974964). MRC2 is expressed in several cells and organs including fibroblasts, endothelial cells, and macrophages. Altered MRC2 expression has been associated with the development and progression of different cancers, including head and neck squamous cell carcinoma, breast cancer, hepatocellular cancer, and prostate cancer (PMID: 36188226; 37666484; 17974964; 25162823). |
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