Mesothelin Recombinant monoclonal antibody proteintech 83744-2-RR
$449.00
In stock
SKU
83744-2-RR
MSLN, 240795G5, CAK1, CAK1 antigen, Megakaryocyte-potentiating factor
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: mesothelin |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 69 kDa, 40 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: MSLN |
| Conjugate: Unconjugated | Gene Symbol: 10232 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671343 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: Mesothelin (MSLN) is a 40kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy (PMID: 20922056, 18691948, 15217923). |
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