LAMB2 Recombinant monoclonal antibody proteintech 82946-1-RR
$449.00
In stock
SKU
82946-1-RR
230143E4, Laminin 11 subunit beta, Laminin 14 subunit beta, Laminin 15 subunit beta, Laminin 3 subunit beta
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: laminin, beta 2 (laminin S) |
| Applications: WB, IHC, FC (Intra), ELISA | Observed Molecular Weight: 195-200 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: LAMB2 |
| Conjugate: Unconjugated | Gene Symbol: 3913 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670688 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: LAMB2 (laminin subunit beta 2), also known as LAMS. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. This gene encodes the beta chain isoform laminin, beta 2. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. The calculated molecular?weight of LAMB2?is?200 kDa. |
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