OGG1 Polyclonal antibody proteintech 30302-1-AP
$449.00
In stock
SKU
30302-1-AP
Ogg 1, N-glycosylase/DNA lyase, DNA-(apurinic or apyrimidinic site) lyase, 8-oxoguanine DNA glycosylase, 8 oxoguanine DNA glycosylase
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, rat | Immunogen: 8-oxoguanine DNA glycosylase |
| Applications: WB, ELISA | Observed Molecular Weight: 36-40 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: OGG1 |
| Conjugate: Unconjugated | Gene Symbol: 4968 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2935539 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:500-1:1000 | Conjugate: Liquid |
| Tested Reactivity: Human, Rat | Form: Antigen affinity purification |
| Host / Isotype: Polyclonal | Background Information: The DNA damages induced by ROS contain base modification, base loss, and DNA single strand breaks, which are usually repaired by the base excision repair (BER) pathway in both prokaryotes and eukaryotes. OGG1 (The human 8-oxoguanine glycosylase 1) is the primary enzyme in BER pathway, responsible for the excision of 7, 8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct that occurs as a result of exposure to reactive oxygen species. There's 8 isoforms of OGG1, with calculated MW 22 kDa, 36-40 kDa and 45-57 kDa. The difference among these isoforms is the C-terminal (317-345aa). |
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