IL-1RA? Recombinant monoclonal antibody proteintech 83335-4-RR
$449.00
In stock
SKU
83335-4-RR
IL-1RN, Il1rn, Interleukin-1, IL-1RA, IL 1ra
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: mouse | Immunogen: interleukin 1 receptor antagonist |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 18 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: IL-1RA |
| Conjugate: Unconjugated | Gene Symbol: 16181 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670997 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: Interleukin-1 receptor antagonist (IL-1RA) is a critical member of the IL-1 family of cytokines, which plays a significant role in modulating inflammatory responses. IL-1RA exists in two main forms: a secreted form (sIL-1Ra) and an intracellular form (icIL-1Ra). The secreted form is produced by various cells including monocytes, macrophages, neutrophils, and other cells, while the intracellular form is found in keratinocytes and other epithelial cells, as well as in monocytes and fibroblasts. IL-1RA is important in host defense against endotoxin-induced injury and is produced in numerous experimental animal models of disease, as well as in human autoimmune and chronic inflammatory diseases. It acts as an anti-inflammatory agent by maintaining the balance between pro-inflammatory IL-1α/β and its own anti-inflammatory effects. |
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