IFITM2 Recombinant monoclonal antibody proteintech 83455-5-RR
$449.00
In stock
SKU
83455-5-RR
1 8D, 18D, 240318B6, DSPA2c, IFITM 2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: interferon induced transmembrane protein 2 (1-8D) |
| Applications: WB, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: 15 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: IFITM2 |
| Conjugate: Unconjugated | Gene Symbol: 10581 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671091 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in a p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also, they serve as important components of the innate immune system to restrict HIV-1 infection. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
