HORMAD1 Recombinant monoclonal antibody proteintech 84003-5-RR
$449.00
In stock
SKU
84003-5-RR
241117E3, CT46, HORMA domain-containing protein 1, HORMAD 1, NOHMA
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: HORMA domain containing 1 |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 50-55 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: HORMAD1 |
| Conjugate: Unconjugated | Gene Symbol: 84072 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671574 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: HORMA domain-containing proteins regulate interactions between homologous chromosomes (homologs) during meiosis in a wide range of eukaryotes [PMID:21079677]. They also implicated in other processes related to crossover formation, including DSB formation, inhibition of promiscuous formation of the synaptonemal complex (SC), and the meiotic prophase checkpoint that monitors both DSB processing and SCs [PMID:19851446]. HORMAD1 first accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I. As germ cells progress into the pachytene stage, HORMAD1 disappears from the synapsed chromosomal regions. However, once the chromosomes desynapse during the diplotene stage, HORMAD1 again accumulates on the chromosome axis of the desynapsed homologs [PMID:19686734]. |
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