GSDMD Recombinant monoclonal antibody proteintech 80918-1-RR
$449.00
In stock
SKU
80918-1-RR
2N24, FKSG10, gasdermin D, Gasdermin domain-containing protein 1, gasderminD
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: gasdermin D |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 50-53 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: GSDMD |
| Conjugate: Unconjugated | Gene Symbol: 79792 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2918919 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:2000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: GSDMD is a 53?kDa cytosolic protein and a member of the gasdermin protein family, which features 6 members in humans (GSDMA, -B, -C, -D, -E and -F. GSDMD was identified as the executioner of inflammasome-associated pyroptosis. Caspase-1, -11, or -4 cleave GSDMD after an aspartate residue within a central linker domain (D275 in humans and D276 in mice) to generate a 31-kDa N-terminal GSDMD fragment (GSDMD-NT) and a 22-kDa C-terminal fragment (GSDMD-CT). In addition to the canonical 31/22 kDa cleavage products, a 43 kDa fragment has been observed under specific experimental or pathological conditions. The generation of the 43?kDa fragment was observed upon caspase-3 and -7 activation during apoptosis. This antibody can only detect full-length GSDMD. |
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