Geminin Recombinant monoclonal antibody proteintech 84199-2-RR
$449.00
In stock
SKU
84199-2-RR
GMNN, 240835B5, Gem, MGORS6
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: geminin, DNA replication inhibitor |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 28-29 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: GMNN |
| Conjugate: Unconjugated | Gene Symbol: 51053 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671755 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:500-1:2000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: GMNN, also designated geminin, contains 212 amino acids and has a destruction box sequence (RRTLKVIQP). GMNN participates in inhibiting DNA replication by preventing the incorporation of MCM complex into the pre-replication complex (pre-RC). It is degraded during the metaphase-anaphase transition of cell cycle's mitotic phase, which permits replication in the succeeding cell cycle. GMNN has a broad sedimentation profile ranging from about 25 kDa to 90 kDa, with a major peak at 30 kDa. Scanning of the signals shows that discrete peaks corresponding to the apparent mass of 42.5 kDa and 66 kDa are present. The dimer of geminin(50 kDa) can also be detected. (PMID: 15313623) |
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