ECSIT Recombinant monoclonal antibody proteintech 83295-1-RR
$449.00
In stock
SKU
83295-1-RR
SITPEC, Protein SITPEC, ECSIT homolog (Drosophila), 240223A7
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: ECSIT homolog (Drosophila) |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 49 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ECSIT |
| Conjugate: Unconjugated | Gene Symbol: 51295 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670961 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: ECSIT is a cytosolic adaptor protein associated with the toll-like receptor pathway. It has a distinct N-terminal mitochondrial targeting sequence, pentatricopeptide repeat motif, and a C-terminal pleckstrin homology domain. ECSIT regulates many biological processes like embryonic development, inflammation, cardiac function, and assembly of mitochondrial complex I. In macrophages, the activation of TLRs by inflammatory signals promotes the translocation of TRAF6 to mitochondria where it engages ECSIT to stimulate the production of mitochondrial reactive oxygen species (ROS). |
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