DROSHA Polyclonal antibody proteintech 27958-1-AP
$449.00
In stock
SKU
27958-1-AP
RNASEN, EC:3.1.26.3, ETOHI2, HSA242976, p241
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: human | Immunogen: CatNo: Ag27533 Product name: Recombinant human DROSHA protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 353-550 aa of NM_001100412 Sequence: MHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHS Predict reactive species |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 159 aa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_001100412 |
| Conjugate: Unconjugated | Gene Symbol: DROSHA |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 29102 |
| Application: Western Blot (WB) | RRID: AB_2918137 |
| Dilution: WB : 1:2000-1:16000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: DROSHA, also named as RN3, RNASE3L, P241 and RNASEN, is double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. It is a component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNASEN/DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. RNASEN is involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. And it is involved in the formation of GW bodies. The antibody is specific to DROSHA. |
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