CXCL10/IP-10 Recombinant monoclonal antibody proteintech 85307-2-RR
$449.00
In stock
SKU
85307-2-RR
CXCL10, CXCL10/IP10, IP10, 10 kDa interferon gamma-induced protein, C X C motif chemokine 10
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: chemokine (C-X-C motif) ligand 10 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 11 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: CXCL10 |
| Conjugate: Unconjugated | Gene Symbol: 3627 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:1000-1:5000 | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: P02778 |
| Host / Isotype: Recombinant | Background Information: CXCL10 (also known as IP-10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is a 12-kDa protein and constitutes two internal disulfide cross bridges. The predicted signal peptidase cleavage generates a 10-kDa secreted polypeptide with four conserved cysteine residues in the N-terminal. The CXCL10 gene localizes on chromosome 4 at band q21, a locus associated with an acute monocytic/B-lymphocyte lineage leukemia exhibiting translocation of t (4; 11) (q21; q23). CXCL10 mediates leukocyte trafficking, adaptive immunity, inflammation, haematopoiesis and angiogenesis. Under proinflammatory conditions CXCL10 is secreted from a variety of cells, such as leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes in response to IFN-γ. |
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