CD53 Recombinant monoclonal antibody proteintech 85838-3-RR
$449.00
In stock
SKU
85838-3-RR
Cell surface glycoprotein CD53, Leukocyte surface antigen CD53
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: mouse | Immunogen: CD53 antigen |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 35-40 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: Cd53 |
| Conjugate: Unconjugated | Gene Symbol: 12508 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:500-1:2000 | Conjugate: Protein A purification |
| Tested Reactivity: Mouse | Form: Q61451 |
| Host / Isotype: Recombinant | Background Information: CD53 is also named as MOX44 and Tetraspanin-25 (Tspan-25). Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment (PMID: 32440787). T cells depend on the phosphatase CD45 to initiate T cell receptor signaling. CD53 is shown to stabilize CD45 on the membrane and is required for optimal phosphatase activity and subsequent Lck activation. Together, CD53 as a regulator of CD45 activity required for T cell immunity (PMID: 35767951). CD53 is a marker for positively selected CD4+ CD8+ thymocytes (PMID: 11867561). |
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