CD46 Recombinant monoclonal antibody proteintech 84599-5-RR
$449.00
In stock
SKU
84599-5-RR
241764F8, MCP, Membrane cofactor protein, MIC10, TLX
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: CD46 molecule, complement regulatory protein |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 50-65 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: CD46 |
| Conjugate: Unconjugated | Gene Symbol: 4179 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:500-1:2000 | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: P15529-11 |
| Host / Isotype: Recombinant | Background Information: CD46, also known as Membrane cofactor protein (MCP) or MIC10, is a ubiquitously expressed type type-I transmembrane glycoprotein that acts as a cofactor for complement factor I to mediate inactivation of C3b and C4b deposited on host cells. CD46 is a receptor for a large number of pathogens, including measles virus and adenovirus (PMID: 20941397). CD46 plays a role in linking innate and adaptive immune responses. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations of the CD46 gene have been associated with some diseases including hemolytic uremic syndrome (PMID: 26054645). CD46 is expressed on most cells as four isoforms that are derived via alternative splicing (PMID: 15324743). |
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