CD3 Delta Recombinant monoclonal antibody proteintech 84214-4-RR
$449.00
In stock
SKU
84214-4-RR
CD3D, 241523H2, CD3-delta, T cell receptor T3 delta chain, T3D
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: CD3d molecule, delta (CD3-TCR complex) |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 20-25 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: CD3 Delta |
| Conjugate: Unconjugated | Gene Symbol: 915 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: P04234 |
| Host / Isotype: Recombinant | Background Information: CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells. CD3 delta/CD3D is a single-pass type I membrane protein which consists of an extracellular domain of 84 amino acids, a transmembrane region, and a cytoplasmic domain of 45 amino acids. Defects in CD3 delta are a cause of severe combined immunodeficiency. |
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