CD163 Recombinant monoclonal antibody proteintech 83285-4-RR
$449.00
In stock
SKU
83285-4-RR
240233A3, M130, sCD163
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: mouse, rat | Immunogen: CD163 antigen |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 160-170 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: Cd163 |
| Conjugate: Unconjugated | Gene Symbol: 93671 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670952 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:12000 | Conjugate: Liquid |
| Tested Reactivity: Mouse, Rat | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: CD163, also known as M130, is a membrane glycoprotein that belongs to the scavenger receptor superfamily (PMID: 8370408). It is an acute phase-regulated and signal-inducing macrophage protein expressed exclusively in monocytes and tissue macrophages (PMID: 11196644). CD163 mediates endocytosis of haptoglobin-haemoglobin complexes (PMID: 11196644). The uptake of haptoglobin by macrophages contributes to the recycling of iron and also to the inflammatory response (PMID: 22900885). Soluble CD163 (sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity (PMID: 12570164). |
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