BUB1B Recombinant monoclonal antibody proteintech 83920-6-RR
$449.00
In stock
SKU
83920-6-RR
BubR1, 240969F7, Bub1A, BUB1beta, EC:2.7.11.1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: budding uninhibited by benzimidazoles 1 homolog beta (yeast) |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 130 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BubR1 |
| Conjugate: Unconjugated | Gene Symbol: 701 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671500 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: BUB1B(Mitotic checkpoint serine/threonine-protein kinase BUB1 beta), also named as BUBR1, MAD3, and SSK1, belongs to the BUB1 subfamily. Human BUB1B is a 120 kDa protein that plays a central role in the spindle assembly checkpoint (SAC), the evolutionary conserved and self-regulatory system of higher organisms that monitors and repairs defects in chromosome segregation in mitotic cells(PMID: 22201036). In addition to phosphorylation, BUB1B is also subjected to posttranslational modifications, including acetylation(PMID: 22167194). Defects in BUB1B are the cause of the premature chromatid separation trait (PCS) and mosaic variegated aneuploidy syndrome type 1 (MVA1). Research has shown that a BUB1B isoform with a measured MW of about 65 kDa (PMID: 34620840). |
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