ACTN2 Recombinant monoclonal antibody proteintech 85857-4-RR
$449.00
In stock
SKU
85857-4-RR
Actinin alpha 2, actinin, alpha 2, ACTN 2, Alpha actinin 2, Alpha-actinin skeletal muscle isoform 2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: actinin, alpha 2 |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 103 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ACTN2 |
| Conjugate: Unconjugated | Gene Symbol: 88 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Mouse, Rat | Form: P35609 |
| Host / Isotype: Recombinant | Background Information: Alpha actinin 2 (ACTN2) belongs to the alpha-actinin family and is expressed in both skeletal and cardiac muscles, and functions to anchor myofibrillar actin thin filaments and titin to Z-discs (PMID: 30701273). ACTN2 is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. Mutations in ACTN2 are associated with hypertrophic cardiomyopathy, as well as dilated cardiomyopathy and endocardial fibroelastosis (PMID: 20022194, 14567970). |
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