Phospho-Hamartin/TSC1 (Ser511) Recombinant monoclonal antibody proteintech 80340-1-RR
$449.00
In stock
SKU
80340-1-RR
TSC1, TSC 1, TSC, LAM, KIAA0243
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse | Immunogen: Peptide Predict reactive species |
| Applications: WB, IF, FC (Intra), ELISA | Observed Molecular Weight: 130 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_000368 |
| Conjugate: Unconjugated | Gene Symbol: Hamartin/TSC1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7248 |
| Application: Western Blot (WB) | RRID: AB_2918889 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: TSC1, also named as Hamartin, is a tumor suppressor gene syndrome whose manifestations can include seizures, mental retardation, autism, and tumors in the brain, retina, kidney, heart, and skin. The tuberous sclerosis 1 (TSC1)/TSC2 tumor suppressor complex serves as a repressor of the mTOR pathway, and disruption of TSC1/TSC2 complex function may contribute to tumorigenesis. TSC1 is phosphorylated by IKKb at Ser487 and Ser511 in vitro and in vivo, and phosphorylation at these sites enhances dissociation of the TSC1/TSC2 complex, which in turn induces mTOR activation. (PMID:?17693255). TSC1 is also threonine-phosphorylated at three sites (Thr417, Ser584, and Thr1047) in a reaction catalyzed by cyclin-dependent kinase 1 (CDK1) (PMID:?14551205). |
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