Phospho-Beta Catenin (Ser675) Recombinant monoclonal antibody proteintech 80084-1-RR
$449.00
In stock
SKU
80084-1-RR
Beta Catenin (Ser675), p Beta Catenin, p Beta Catenin (Ser675), p Beta Catenin Ser675, p-Beta Catenin
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse, rat | Immunogen: Peptide Predict reactive species |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 781 aa, 86 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC058926 |
| Conjugate: Unconjugated | Gene Symbol: Beta Catenin |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1499 |
| Application: Western Blot (WB) | RRID: ENSG00000168036 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: AB_2918863 |
| Tested Reactivity: Human, Mouse, Rat | Form: Unconjugated |
| Host / Isotype: Rabbit / IgG | Background Information: β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222). PKA was shown to phosphorylate β-catenin at Ser675. Phosphorylation at Ser675 induces β-catenin accumulation in the nucleus and increases its transcriptional activity. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
