Phospho-AKT1 (Ser473) Recombinant monoclonal antibody proteintech 80462-1-RR
$449.00
In stock
SKU
80462-1-RR
AKT (Ser473), AKT1 (Ser473), p AKT, p AKT (Ser473), p AKT Ser473
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse | Immunogen: Peptide Predict reactive species |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 56-62 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: AKT1 |
| Conjugate: Unconjugated | Gene Symbol: 207 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2918894 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purification |
| Host / Isotype: Rabbit / IgG | Background Information: AKT is a serine/threonine kinase and it participates in the key role of the PI3K signaling pathway. Phosphatidylinositol-3 kinase (PI3K) is the key regulator of AKT activation. The recruitment of inactive AKT protein to PIP3-rich areas of the plasma membrane results in a conformational change that exposes the activation loop of AKT. AKT's activating kinase, phosphoinositide-dependent protein kinase (PDK1) , is also recruited to PIP3 microdomains. PDK1 phosphorylates AKT on threonine 308 (Thr308) of the exposed activation loop, activating AKT and leading to a second phosphorylation of AKT at serine 473 (Ser473) by a kinase presumed to be mTORC2 that further potentiates kinase activity. Active AKT will phosphorylate various downstream protein targets that control cell growth and translational control and act to suppress apoptosis. (PMID:?31594388, PMID:?30808672). 80462-1-RR specifically recognizes AKT1 phosphorylated at Ser473. |
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