TPR Recombinant monoclonal antibody proteintech 83177-5-RR
$449.00
In stock
SKU
83177-5-RR
Nucleoprotein TPR, 230413A2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: translocated promoter region (to activated MET oncogene) |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: ~270 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: TPR |
| Conjugate: Unconjugated | Gene Symbol: 7175 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670870 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:500-1:2000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Nucleoporin TPR was originally identified as the oncogenic activator of the met, raf, and trk protooncogenes. TPR is a large 270 kDa protein with a bipartite structure consisting of a ~1600-residue a-helical coiled-coil N-terminal domain and a highly acidic non-coiled ~800 amino acid carboxy terminus (PMID: 22253824). TPR is localized exclusively to intranuclear filaments associated with the nucleoplasmic side of the NPC, by directly binding to Nup153 (PMID: 12802065). |
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