NAT10 Recombinant monoclonal antibody proteintech 82585-1-RR
$449.00
In stock
SKU
82585-1-RR
N acetyltransferase 10, KIAA1709, EC:2.3.1.-, ALP, 5B9
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: N-acetyltransferase 10 (GCN5-related) |
| Applications: WB, IF/ICC, IP, ELISA | Observed Molecular Weight: 116 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NAT10 |
| Conjugate: Unconjugated | Gene Symbol: 55226 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3086490 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: NAT10 (N-acetyltransferase 10) is a nucleolar protein that is involved in regulation of telomerase activity, DNA damage response, and cytokinesis. It also plays a role in maintaining nuclear shape. Inhibition of NAT10 has been reported to rescue the misshapen nuclei in laminopathic cells via microtubule reorganization. The specificity of this antibody has been tested by siRNA (PMID: 24786082). NAT10 regulates mitotic cell fate by acetylating Eg5. NAT10 depletion results in multinuclear giant cells, which is the hallmark of mitotic catastrophe (PMID: 35210604). NAT10 plays a crucial role in carcinogenesis through influencing EMT, hypoxia, ribosomal biogenesis and overall, promoting translational efficiency. Recently, we reported that treating cancer cells with Remodelin, a small molecule inhibitor of NAT10, causes alteration in global lipid metabolism (PMID: 36149760). |
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