IDH2 Recombinant monoclonal antibody proteintech 82117-1-RR
$449.00
In stock
SKU
82117-1-RR
IDHM, IDH 2, ICD-M, ICD M, EC:1.1.1.42
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| Applications: WB, IHC, IP, ELISA | Observed Molecular Weight: 43 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: IDH2 |
| Conjugate: Unconjugated | Gene Symbol: 3418 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3086464 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rat | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: IDH2, also named as IDP and ICD-M, belongs to the isocitrate and isopropylmalate dehydrogenases family. It plays a role in intermediary metabolism and energy production. IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. It may tightly associate or interact with the pyruvate dehydrogenase complex. IDH1 and IDH2 mutations could also contribute to tumorigenesis and cancer progression through increased mutagenesis. IDH2 has 2 isoforms with the MW of 51 kDa and 45 kDa, and the mature form is about 47 kDa and 41 kDa with the N-terminal transit peptide cleaved. |
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