CD141/Thrombomodulin Recombinant monoclonal antibody proteintech 84412-3-RR
$449.00
In stock
SKU
84412-3-RR
241730D4, CD141, Fetomodulin, Thbd, Thrombomodulin
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: mouse | Immunogen: thrombomodulin |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 105 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: Thbd |
| Conjugate: Unconjugated | Gene Symbol: 21824 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671941 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310). |
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