CCAR1 Recombinant monoclonal antibody proteintech 83936-4-RR
$449.00
In stock
SKU
83936-4-RR
240980C12, CARP 1, CARP1, CARP-1, Death inducer with SAP domain
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: cell division cycle and apoptosis regulator 1 |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 150 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: CCAR1 |
| Conjugate: Unconjugated | Gene Symbol: 55749 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671518 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Cell cycle and apoptosis regulator 1 (CCAR1) was originally identified from a functional screening and implicated in retinoid-induced cell cycle arrest and apoptosis. It has been shown that, in breast cancer cells, CCAR1 regulates apoptosis induced by various agents, including chemotherapeutics adriamycin, etoposide, and EGFR inhibitor. It is also involved in mediating anchorage-independent growth of colon carcinoma cells. In addition, CCAR1 plays the role as a co-activator of nuclear receptors to recruit mediator complex. It was found to associate with components of the Mediator and p160 coactivator complexes and is recruited to endogenous NR target genes. CCAR1 is also a binding partner of b-catenin and assists b-catenin in transcriptional activation of Wnt target genes. |
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