PCM1 Recombinant monoclonal antibody proteintech 84979-1-RR
$449.00
In stock
SKU
84979-1-RR
242199A9, hPCM 1, hPCM-1, PCM 1, PCM-1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: pericentriolar material 1 |
| Applications: WB, IHC, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: 245-320 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: PCM1 |
| Conjugate: Unconjugated | Gene Symbol: 5108 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Protein A purfication |
| Tested Reactivity: Human, Mouse | Form: Q15154 |
| Host / Isotype: Recombinant | Background Information: Pericentriolar material 1 (PCM1) is a component of centriolar satellites, which are electron dense granules scattered around centrosomes (PMID: 10579718). PCM1 is required for centrosome assembly and function. It acts as a scaffold to target several proteins to the centrosome in a dynein motor-dependent manner and regulate microtubular dynamics (PMID:18762586; 12403812). It is also involved in the biogenesis of cilia (PMID: 18772192). Chromosomal aberrations involving PCM1 gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. (PMID: 10980597; 16091753; 15805263; 16424865). |
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