Caspase 1 Recombinant monoclonal antibody proteintech 81482-1-RR
$449.00
In stock
SKU
81482-1-RR
CASP1, Caspase1, 1O18, CASP 1, CASP-1
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: Human And More (2) | Immunogen: CatNo: Ag11143 Product name: Recombinant human Caspase 1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-311 aa of BC062327 Sequence: MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 404 aa, 45 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC062327 |
| Conjugate: Unconjugated | Gene Symbol: Caspase 1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 834 |
| Application: Western Blot (WB) | RRID: AB_2935555 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing. 81482-1-RR can recognize the 45 kDa Pro-Caspase1 and the 30-35 kDa splicing isoforms or active dimer form of caspase 1. |
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