SMAD2 Recombinant monoclonal antibody proteintech 83841-4-RR
$449.00
In stock
SKU
83841-4-RR
240950F1, hMAD 2, hMAD-2, hSMAD2, JV18
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, rat | Immunogen: SMAD family member 2 |
| Applications: WB, IF/ICC, FC (Intra), ELISA, ChIP-qPCR | Observed Molecular Weight: 58 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SMAD2 |
| Conjugate: Unconjugated | Gene Symbol: 4087 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671425 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Rat | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: SMAD2, also named as MADH2 and MADR2, belongs to the dwarfin/SMAD family, contains 1 MH1 (MAD homology 1) domain and 1 MH2 (MAD homology 2) domain. SMAD2 is a receptor-regulated SMAD(R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. This protein may act as a tumor suppressor in colorectal carcinoma. It is phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, It is phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases, and then able to interact with SMURF2, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, it is phosphorylated on Ser-240 by CaMK2. It is phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. In response to TGF-beta, it is ubiquitinated by NEDD4L, which promotes its degradation. In response to TGF-beta signaling, it is acetylated on Lys-19 by coactivators, which increases transcriptional activity. The molecular weight of unphosphorylated forms of Smad2 is 52 kDa and phosphorylated forms of Smad2 is 58 kDa. (PMID: 9006934) |
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