Calsequestrin 2 Monoclonal antibody proteintech 66419-1-Ig
$449.00
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66419-1-Ig
| Host / Isotype: Mouse / IgG2a | Class: Monoclonal |
| Reactivity: human, rat, pig, mouse | Immunogen: CatNo: Ag13246 Product name: Recombinant human CASQ2 protein Source: e coli.-derived, T-HIS Tag: 6*His Domain: 1-399 aa of BC022288 Sequence: MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDLLCLYYHEPVSSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELVEFVKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTAEELEDWIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE Predict reactive species |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 46 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC022288 |
| Conjugate: Unconjugated | Gene Symbol: Calsequestrin 2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 845 |
| Application: Western Blot (WB) | RRID: AB_2881791 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: human, rat, pig, mouse | Form: Liquid |
| Host / Isotype: Mouse / IgG2a | Background Information: Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. |
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