IRE1/ERN1 Polyclonal antibody proteintech 27528-1-AP
$449.00
In stock
SKU
27528-1-AP
ERN1, IRE1; ERN1, Endoplasmic reticulum-to-nucleus signaling 1, Endoribonuclease, ERN 1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (2) | Immunogen: CatNo: Ag25580 Product name: Recombinant human IRE1; ERN1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 368-565 aa of BC130405 Sequence: PLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVI Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), IP, CoIP, ELISA | Observed Molecular Weight: 977 aa, 110 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC130405 |
| Conjugate: Unconjugated | Gene Symbol: IRE1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 2081 |
| Application: Western Blot (WB) | RRID: AB_2880899 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. IRE1 contains a ribonuclease domain in its cytoplasmic region which initiates splicing reaction by direct cleavage of XBP1 mRNA at the two stem loop structures. IRE1 plays instrumental protumoral roles in several cancers, and high IRE1 activity has been associated with poorer prognoses. (PMID: 23880584, PMID: 32861679, PMID: 31875595) |
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