PERK/EIF2AK3 Polyclonal antibody proteintech 24390-1-AP
$449.00
In stock
SKU
24390-1-AP
EIF2AK3, PERK, EC:2.7.11.1, EIF2AK 3, Eukaryotic translation initiation factor 2-alpha kinase 3
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (6) | Immunogen: CatNo: Ag18254 Product name: Recombinant human EIF2AK3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 767-1116 aa of BC126354 Sequence: TDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), IP, ELISA | Observed Molecular Weight: 1116 aa, 125 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC126354 |
| Conjugate: Unconjugated | Gene Symbol: PERK |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 9451 |
| Application: Western Blot (WB) | RRID: AB_2879521 |
| Dilution: WB : 1:500-1:3000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PERK, also named as EIF2AK3 or PEK, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and GCN2 subfamily. It acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. PERK and EIF2AK4 also have a functional role on regulating translation under non-stressed conditions, apart from their long established roles as stress kinases (PMID: 21638082). Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS). The molecular mass of PERK is 125 kDa and can be detected as 140 kDa or 170kDa due to some modifications such as glycosylation and phosphorylation (PMID: 20851775, 24371088, 21703327). |
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