SMN-Exon7 Monoclonal antibody proteintech 60255-1-Ig
$449.00
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60255-1-Ig
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag16615 Product name: Recombinant human SMN1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 275-294 aa of BC062723 Sequence: GYYMGFRQNQKEGRCSHSLN Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 294 aa, 32 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC062723 |
| Conjugate: Unconjugated | Gene Symbol: SMN |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 6606 |
| Application: Western Blot (WB) | RRID: AB_2881376 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of anterior horn cells in the spinal cord and concomitant symmetrical muscle weakness and atrophy (PMID: 16364894 ). SMA is caused by deletion or mutations of the survival motor neuron (SMN1) gene. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional (PMID: 17355180). A large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein (PMID: 10369862). The level of SMN protein correlates with phenotypic severity of SMA. This antibody, 60255-1-Ig, raised against the C-terminal region (275-294aa) encoded by the exon 7. |
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